Structure and physicochemical properties of water, for example their dipole moment, results in formation of cluster of water molecules bound together by hydrogen bounding. Formation of water clusters has been investigated in vitro and there are some indications that formation of water clusters can influence aqueous solubility of drugs, especially lipophilic drugs that have only limited solubility in water. Also, there are some indications that water clusters can increase physical stability of molecular aggregates and that formation of such aggregates interferes with high throughput screening for new chemical entities. Furthermore, in vitro studies have indicated that layers of stagnant water molecules could be water clusters. Carbohydrates and glycoproteins at membrane surfaces can perhaps enhance formation of such clusters. Little or no information is available on formation of water clusters in vivo. The purpose of this project is to investigate the influence of cluster formation on ...