PhD Studentship in Molecular Simulation Methods for HIV Treatment, The UCL Centre for Computational Science [UK]

PhD Studentship in Molecular Simulation Methods for HIV Treatment, The UCL Centre for Computational Science, UK

The UCL Centre for Computational Science seeks to appoint a PhD student, funded by the UCLH/UCL Comprehensive Biomedical Research Centre (CBRC), to pursue an interdisciplinary, translational research project in the area of patient specific HIV drug treatment, using genotypic molecular simulation.

The project will be supervised by Professor Peter Coveney (UCL Centre for Computational Science) and Professor Deenan Pillay (UCL Centre for Infection), and will involve:

  • Analysis/development of current and alternative methods for molecular binding affinity calculation, for HIV enzymes and their anti-retroviral ligands
  • Development of a HIV-1 integrase/inhibitor binding affinity calculation system
  • Establishment of links with experimentalists to facilitate validation of findings from simulations and provide information on novel mutations and anti-retroviral mutational pathways to be investigated
  • Incorporation of new/improved HIV drug/enzyme simulations into patient–specific a treatment evaluation and decision support pipeline.

The position is available to both UK and EU applicants, who must have a very good first degree in a relevant subject (Chemistry/Physics, Mol. Virology, Computer Science), an affinity for and interest in biological sciences, and be willing to integrate and progress their knowledge across these disciplines.

Students will register during the 2009/10 academic year for a three year full-time MPhil/PhD degree, with an expected commencement date of 1st October 2009. Funding includes UK/EU tuition fees and a tax-free stipend equivalent to the MRC rate of £15,100 (in 2008/9).

Further information about the project can be found at:

To apply, please send a covering letter, application form and CV by email to Nilufer Betik (n.betik[ at ], including the contact details of at least two academic referees. Application forms and details of the admissions process are available online at this page.

Informal inquiries can be made to Professor P V Coveney by email (p.v.coveney[ at ]

The closing date for applications is Friday 15th May, 2009.

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