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Postdoctoral Fellowship - Cell Biology, University of Debrecen, Hungary

Reference: MRTN_CT_2006_035946
Summary: Looking for a candidate with background in one or more of biophysics, molecular and cell biology, immunology, microscopic imaging to investigate molecular interactions between MHC class I and II molecules and TCR receptor in immune synapse formation.

Description
A Postdoctoral fellowship (2 years) is available within the framework of a Marie Curie Research Training Network (Immunanomap, MRTN_CT_2006_035946).

Research objectives: The topology, conformation and lateral mobility of the membrane proteins during this process play an important role in these processes. We would also like to investigate the changes of the cell surface distribution of MHC class I and II molecules. We aim to discover connections between the immunological function of MHC molecules and their supercluster formation on cells with modified expression levels by studying the rotational and lateral mobility of these receptor complexes using the available up-to-date spectroscopic and microscopic techniques (e.g. fluorescence correlation microscopy).

Adoptive transfer of antigen-specific T cells, recently shown therapeutic success in the treatment of cancers T cells, can be generated in vitro, bypassing in vivo constraints that often influence an effective T cell response. TCR molecules will be genetically modified and transfected back to T cells. The aim of genetic modification of TCR alpha and beta chains is to improve alpha and beta pairing and signal transduction efficacy of the constructs. Modified TCR chains are compared to non-modified TCR in vitro for their stochiometry and correct TCR pairing via FRET based flow cytometric and microscopic techniques.

Quasi-realtime observation of the dynamics of molecular interactions, localization, and translocation between cellular compartments of immunocompetent molecules in immune synapse formation is of general interest within the Network (www.immunanomap.eu)

Benefits

Salary and allowance based on EU regulations relating to the Marie-Curie training programme. (In Hungary salary would be around EURO 28,000.- per year and supports for study trips around EURO 4,400.- per year.

Requirements

Recent Ph.D. degree in Biological / Medical Sciences. The Applicant cannot be a Hungarian citizen unless he/she has lived outside the country for more than 5 years. EU citizenship preferable. Publications in refereed journals strenghtens the application of the candidate.

Application

Please list your skills, experiences, publications, etc, all merits in your application. Give name/address of 2 people who can be contacted for references. Email or send this by post to:

University of Debrecen, Medical and Health Science Center
Department of Biophysics and Cell Biology
Nagyerdei krt. 98
Debrecen 4032, Hungary
Tel: 36 52 423 331 or 36 52 412 623
Email: szollo@dote.hu
Web: www.biophys.dote.hu/research.htm

Deadline: November 30, 2007
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